The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a
chorus of factors. Here, we identified a common binary interaction module consisting of TFIIS …

Abstract Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …

Eukaryotic transcription is dependent on specific histone modifications. Their recognition by
chromatin readers triggers complex processes relying on the coordinated association of …

Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …

Patients with advanced prostate cancer (PCa) invariably develop resistance to anti-
androgen therapy and taxane-based chemotherapy. Glucocorticoid receptor (GR) has been …

Introduction: Anti-DFS70 antibodies and their clinical associations remain an immunological
paradox. Unlike other antinuclear antibodies (ANA), there is a growing body of evidence that …

The discovery and initial characterization 20 years ago of antinuclear autoantibodies (ANAs)
presenting a dense fine speckled (DFS) nuclear pattern with strong staining of mitotic …