Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …

Depending on cell type, environmental inputs, and disease, the cells in the human body can
have widely different sizes. In recent years, it has become clear that cell size is a major …

A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …

CDK4/6 inhibitors are remarkable anti-cancer drugs that can arrest tumor cells in G1 and
induce their senescence while causing only relatively mild toxicities in healthy tissues. How …

Cell dry mass is principally determined by the sum of biosynthesis and degradation.
Measurable change in dry mass occurs on a time scale of hours. By contrast, cell volume …

To achieve a stable size distribution over multiple generations, proliferating cells require a
means of counteracting stochastic noise in the rate of growth, the time spent in various …

Cell proliferation is a central process in tissue development, homeostasis, and disease, yet
how proliferation is regulated in the tissue context remains poorly understood. Here, we …

The skeletal muscle research field generally accepts that nuclei in skeletal muscle fibers (ie,
myonuclei) are post-mitotic and unable to proliferate. Because our deuterium oxide (D2O) …

How flexible developmental programs integrate information from internal and external
factors to modulate stem cell behavior is a fundamental question in developmental biology …

Senescence, a state of irreversible cell-cycle withdrawal, is difficult to distinguish from
quiescence, a state of reversible cell-cycle withdrawal. This difficulty arises because …