Biological applications of dendrimers

MJ Cloninger - Current opinion in chemical biology, 2002 - Elsevier
In the past year, significant advances have been made in the synthesis and study of
glycodendrimers and peptide dendrimers. Application of these dendrimers to the study of …

Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate–protein interactions

Á Martínez, CO Mellet, JMG Fernández - Chemical Society Reviews, 2013 - pubs.rsc.org
Covalent attachment of biorecognizable sugar ligands in several copies at precise positions
of cyclomaltooligosaccharide (cyclodextrin, CD) macrocycles has proven to be an extremely …

Synthetic routes to thiooligosaccharides and thioglycopeptides

K Pachamuthu, RR Schmidt - Chemical reviews, 2006 - ACS Publications
The ongoing ability of bacteria to resist current antibiotic treatments highlights the need for
alternative strategies for inhibiting their pathogenicity. For many pathogens, including …

Multivalent ligand presentation as a central concept to study intricate carbohydrate–protein interactions

N Jayaraman - Chemical society reviews, 2009 - pubs.rsc.org
Studying the weak binding affinities between carbohydrates and proteins has been a central
theme in sustained efforts to uncover intricate details of this class of biomolecular interaction …

Polycationic β-cyclodextrin “click clusters”: monodisperse and versatile scaffolds for nucleic acid delivery

S Srinivasachari, KM Fichter… - Journal of the American …, 2008 - ACS Publications
Herein, a novel series of multivalent polycationic β-cyclodextrin “click clusters” with discrete
molecular weight have been synthesized, characterized, and examined as therapeutic …

[图书][B] Synthetic multivalent molecules: concepts and biomedical applications

S Choi - 2004 - books.google.com
This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

PAMAM dendrimers: destined for success or doomed to fail? Plain and modified PAMAM dendrimers in the context of biomedical applications

M Labieniec-Watala, C Watala - Journal of pharmaceutical sciences, 2015 - Elsevier
PAMAM (polyamidoamine) dendrimers are commonly considered promising polymers that
can be successfully used in various biomedical applications. Nevertheless, direct clinical …

Molecular dynamics studies of native and substituted cyclodextrins in different media: 1. Charge derivation and force field performances

C Cézard, X Trivelli, F Aubry… - Physical Chemistry …, 2011 - pubs.rsc.org
Molecular dynamics simulations describing the solvation process of native and modified
cyclodextrins (per-substituted α-, β-, and γ-cyclodextrins, as well as an amino-acid derived β …

Recent advances in intravenous delivery of poorly water-soluble compounds

Y Shi, W Porter, T Merdan, LC Li - Expert opinion on drug delivery, 2009 - Taylor & Francis
In recent years, with the widespread application of high-throughput screening technologies
in drug discovery, an increasing number of new chemical entities with extremely poor …

Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors

H Arima, K Motoyama, T Higashi - Advanced drug delivery reviews, 2013 - Elsevier
The widespread use of various cyclodextrin (CyD)-appended polymers and polyrotaxanes
as gene carriers has been reported. Among the various polyamidoamine dendrimer …