Reactive oxygen species have been implicated in brain injury after ischemic stroke. These
oxidants can react and damage the cellular macromolecules by virtue of the reactivity that …

NO was first characterized in the CNS as the intercellular messenger mediating the increase
in cyclic GMP levels that follows activation of glutamate receptors (Garthwaite et al., 1988) …

Glutamate binds to both excitatory neurotransmitter binding sites and a W-dependent,
quisqualate-and cystine-inhibited transport site on brain neurons. The neuroblastoma …

Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels,
cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate …

The NADPH-diaphorase histochemical technique provides a simple and robust method to
stain select populations of neurons throughout the brain. We have recently identified the …

Using the fluorescent dye 2′, 7′-dichlorodihydrofluorescein (DCF-H2) we investigated the
role of glutamate in the production of reactive oxygen species (ROS) in cultured neurons …

NADPH diaphorase histochemistry selectively labels a number of discrete populations of
neurons throughout the nervous system. This simple and robust technique has been used in …

NADPH diaphorase staining neurons, uniquely resistant to toxic insults and
neurodegenerative disorders, have been colocalized with neurons in the brain and …

In a remarkably brief period of time, NO and CO have been recognized as putative
neurotransmitters. These two novel messenger molecules have greatly expanded the …

▪ Abstract Zinc is an essential catalytic or structural element of many proteins, and a
signaling messenger that is released by neural activity at many central excitatory synapses …