What is the duration of untreated psychosis worldwide?–A meta-analysis of pooled mean and median time and regional trends and other correlates across 369 …

GS De Pablo, C Aymerich, D Guinart… - Psychological …, 2024 - cambridge.org
Duration of untreated psychosis (DUP) has been associated with poor mental health
outcomes. We aimed to meta-analytically estimate the mean and median DUP worldwide …

BDNF and schizophrenia: from neurodevelopment to neuronal plasticity, learning, and memory

R Nieto, M Kukuljan, H Silva - Frontiers in psychiatry, 2013 - frontiersin.org
Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been related not only
to neurodevelopment and neuroprotection, but also to synapse regulation, learning, and …

Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies

BS Fernandes, ML Molendijk, CA Köhler, JC Soares… - BMC medicine, 2015 - Springer
Background The neurotrophic hypothesis postulates that mood disorders such as bipolar
disorder (BD) are associated with a lower expression of brain-derived neurotrophic factor …

Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications

BS Fernandes, J Steiner, M Berk, ML Molendijk… - Molecular …, 2015 - nature.com
It has been postulated that schizophrenia (SZ) is related to a lower expression of brain-
derived neurotrophic factor (BDNF). In the past few years, an increasing number of divergent …

Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume

V Mondelli, A Cattaneo, MB Murri… - The Journal of clinical …, 2011 - psychiatrist.com
Background: Reduced brain-derived neurotrophic factor (BDNF) levels have been reported
in the serum and plasma of patients with psychosis. The aim of this cross-sectional case …

Brain derived neurotrophic factor: a novel neurotrophin involved in psychiatric and neurological disorders

S Balaratnasingam, A Janca - Pharmacology & therapeutics, 2012 - Elsevier
Brain Derived Neurotrophic Factor (BDNF) is a unique member of the neurotrophin family
with potent and plethoric effects on the proliferation, differentiation, survival and death of …

The possible role of the Akt signaling pathway in schizophrenia

W Zheng, H Wang, Z Zeng, J Lin, PJ Little… - Brain research, 2012 - Elsevier
Serine/threonine protein kinase v-akt murine thymoma viral oncogene homolog (Akt) is one
of the survival kinases with multiple biological functions in the brain and throughout the …

[HTML][HTML] Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells …

N Davidsen, AJ Lauvås, O Myhre, E Ropstad… - Reproductive …, 2021 - Elsevier
Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances
(PFASs), brominated flame retardants (BFRs), organochlorine pesticides and …

Links between trauma and psychosis

I Giannopoulou, S Georgiades… - Experimental and …, 2023 - spandidos-publications.com
The relationship between trauma and psychosis is complex and multifaceted, with evidence
suggesting that trauma can be both a risk factor for the development of psychosis and a …

Cognitive impairments and low BDNF serum levels in first-episode drug-naive patients with schizophrenia

L Man, X Lv, XD Du, G Yin, X Zhu, Y Zhang… - Psychiatry …, 2018 - Elsevier
Evidence shows that BDNF may regulate activity-dependent forms of synaptic plasticity
underlying learning and memory. Previous studies reported low BDNF levels and cognitive …