Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Cell migration through 3D tissue depends on a physicochemical balance between cell
deformability and physical tissue constraints. Migration rates are further governed by the …

Cell migration is a critical process for diverse (patho) physiological phenomena. Intriguingly,
cell migration through physically confined spaces can persist even when typical hallmarks of …

The nucleus is the defining feature of eukaryotic cells and often represents the largest
organelle. Over the past decade, it has become apparent that the nucleus is tightly …

Various concentration gradient generation methods based on microfluidic systems are
summarized in this paper. The review covers typical structural characteristics, gradient …

Cell motility plays a critical role in many physiological and pathological settings, ranging
from wound healing to cancer metastasis. While cell migration on 2-dimensional (2-D) …

From embryonic development to cancer metastasis, cell migration plays a central role in
health and disease. It is increasingly becoming apparent that cells migrating in three …

Background Cancer invasion is a multi-step process which coordinates interactions between
tumor cells with mechanotransduction towards the surrounding matrix, resulting in distinct …

Metastases, or migration of cancers, are common and severe cancer complications.
Although the 5-year survival rates of primary tumors have greatly improved, those of …