Network pharmacology: curing causal mechanisms instead of treating symptoms
For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …
discovery is in constant decline. While low quality, reproducibility issues, and translational …
[HTML][HTML] A human brain vascular atlas reveals diverse mediators of Alzheimer's risk
The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …
disability and death, and the specialized structure it forms—the blood–brain barrier …
A thrombin‐activated peptide‐templated nanozyme for remedying ischemic stroke via thrombolytic and neuroprotective actions
Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …
[HTML][HTML] Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs
T Zhu, L Wang, L Wang, Q Wan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Neuroprotective and neurorestorative therapy represent two major drug intervention
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …
Ischemic stroke: experimental models and reality
CJ Sommer - Acta neuropathologica, 2017 - Springer
The vast majority of cerebral stroke cases are caused by transient or permanent occlusion of
a cerebral blood vessel (“ischemic stroke”) eventually leading to brain infarction. The final …
a cerebral blood vessel (“ischemic stroke”) eventually leading to brain infarction. The final …
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …
To address this problem, several therapeutic approaches have been proposed, including …
Short-chain fatty acids improve poststroke recovery via immunological mechanisms
Recovery after stroke is a multicellular process encompassing neurons, resident immune
cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has …
cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has …
Apoptosis regulation in the penumbra after ischemic stroke: expression of pro-and antiapoptotic proteins
AB Uzdensky - Apoptosis, 2019 - Springer
Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …
Classification of microglial morphological phenotypes using machine learning
J Leyh, S Paeschke, B Mages, D Michalski… - Frontiers in cellular …, 2021 - frontiersin.org
Microglia are the brain's immunocompetent macrophages with a unique feature that allows
surveillance of the surrounding microenvironment and subsequent reactions to tissue …
surveillance of the surrounding microenvironment and subsequent reactions to tissue …