Dysregulated RNA metabolism is emerging as a crucially important mechanism
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …

Alternative splicing of precursor mRNA is an important mechanism that increases
transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA …

Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …

Growing oocytes store a large amount of maternal mRNA to support the subsequent
“maternal-zygotic transition” process. At present, it is not clear how the growing oocytes store …

Mutations in HNRNPH2 cause an X-linked neurodevelopmental disorder with features that
include developmental delay, motor function deficits, and seizures. More than 90% of …

Monocytes and macrophages are essential components of the innate immune system.
Herein, we report that intron retention (IR) plays an important role in the development and …

Alternative splicing (AS) plays important roles in embryonic stem cell (ESC) differentiation. In
this study, we first identified transcripts that display specific AS patterns in pluripotent human …

Topographical cues on materials can manipulate cellular fate, particularly for neural cells
that respond well to such cues. Utilizing biomaterial surfaces with topographical features can …

Individual variation in the addiction liability of amphetamines has a heritable genetic
component. We previously identified Hnrnph1 (heterogeneous nuclear ribonucleoprotein …

Genome integrity can be threatened by various endogenous or exogenous events. To
counteract these stressors, the DNA damage response network contributes to the prevention …