Endometrial cancer is the most common gynecologic cancer in the United States, and its
incidence is rising. Although there have been significant recent advances in our …

Histopathological evaluation including subty** and grading is the current cornerstone for
endometrial cancer (EC) classification. This provides clinicians with prognostic information …

Highlights•This ESMO Clinical Practice Guideline provides key recommendations for
managing endometrial cancer.•The guideline covers clinical and pathological diagnosis …

PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in
Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of …

BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is
irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive …

In this review, we sought to address 2 important issues in the diagnosis of endometrial
carcinoma: how to grade endometrial endometrioid carcinomas and how to incorporate the …

Background: Classification of endometrial carcinomas (ECs) by morphologic features is
inconsistent, and yields limited prognostic and predictive information. A new system for …

Our aim was to investigate whether molecular classification can be used to refine prognosis
in grade 3 endometrial endometrioid carcinomas (EECs). Grade 3 EECs were classified into …

BACKGROUND Endometrial cancers (ECs) with somatic mutations in DNA polymerase
epsilon (POLE) are characterized by unfavorable pathological features, which prompt …

Endometrial cancer (EC) has four molecular subtypes with strong prognostic value and
therapeutic implications. The most common subtype (NSMP; No Specific Molecular Profile) …