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Discovery of farnesoid X receptor and its role in bile acid metabolism
In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …
[HTML][HTML] Estrogen as a key regulator of energy homeostasis and metabolic health
Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …
Role of thyroid hormones in skeletal development and bone maintenance
The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …
the critical role for thyroid hormones during development, linear growth, and adult bone …
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
Intestinal microbial metabolites are conjectured to affect mucosal integrity through an
incompletely characterized mechanism. Here we showed that microbial-specific indoles …
incompletely characterized mechanism. Here we showed that microbial-specific indoles …
[HTML][HTML] Nuclear receptors, RXR, and the big bang
Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …
hormone and their structural and functional analysis revealed an evolutionarily conserved …
The role and regulation of the peroxisome proliferator activated receptor alpha in human liver
The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …
[HTML][HTML] FXR in liver physiology: Multiple faces to regulate liver metabolism
K Panzitt, M Wagner - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …
[HTML][HTML] Integrated physiology and systems biology of PPARα
Abstract The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription
factor that plays a major role in metabolic regulation. This review addresses the functional …
factor that plays a major role in metabolic regulation. This review addresses the functional …
Bile acid receptors as targets for drug development
The intracellular nuclear receptor farnesoid X receptor and the transmembrane G protein-
coupled receptor TGR5 respond to bile acids by activating transcriptional networks and/or …
coupled receptor TGR5 respond to bile acids by activating transcriptional networks and/or …
Degradation of AMPK by a cancer-specific ubiquitin ligase
AMP-activated protein kinase (AMPK) is a master sensor and regulator of cellular energy
status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic …
status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic …