Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual
physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity …

Spaceflight associated neuro-ocular syndrome (SANS) refers to a unique collection of neuro-
ophthalmic clinical and imaging findings observed in astronauts after long-duration …

Background The cardiovascular system is strongly dependent on the gravitational
environment. Gravitational changes cause mechanical fluid shifts and, in turn, autonomic …

It is well known that exposure to microgravity in astronauts leads to a plethora physiological
responses such as headward fluid shift, body unloading, and cardiovascular deconditioning …

As humanity prepares for deep space exploration, understanding the impact of spaceflight
on bodily physiology is critical. While the effects of non-terrestrial gravity on the body are …

Spaceflight associated neuro‐ocular syndrome (SANS) is hypothesized to develop as a
consequence of the chronic headward fluid shift that occurs in sustained weightlessness …

This line of research may help identify which astronauts are at risk of these ophthalmic
changes, and allow targeted treatment. This research may have implications for clinical …

Microgravity and elevated levels of CO2 are two common environmental stressors in
spaceflight that may affect cognitive performance of astronauts. In this randomized, double …

Astronauts aboard the International Space Station (ISS) have exhibited hyperopic shifts,
posterior eye globe flattening, dilated optic nerve sheaths, and even optic disk swelling from …

To improve the pathophysiological understanding of visual changes observed in astronauts,
we aimed to use quantitative MRI to measure anatomic and physiological responses during …