Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …

Simple Summary CAR T cell therapies have been successful at treating patients with blood
cancers and are now FDA-approved therapies for various types of leukemias and …

Unlocking the potential of engineered immune cell therapy for solid tumors | Nature
Communications Skip to main content Thank you for visiting nature.com. You are using a browser …

Although chimeric antigen receptor (CAR) T-cell (CAR-T) therapy has revolutionized the
treatment of B-cell malignancies, many patients relapse and therefore strategies to improve …

Simple Summary Cancer immune evasion poses a significant challenge in develo**
effective cancer treatments. The interplay between the immune system and tumors …

Adoptive cell therapies (ACT) have shown reduced efficacy against solid tumor
malignancies compared to hematologic malignancies, partly due to the immunosuppressive …

Despite the great success that chimeric antigen receptor (CAR) T-cells have had in patients
with B-cell malignancies and multiple myeloma, they continue to have limited efficacy …

Systemic administration of homeostatic γ-chain cytokines mediates antitumor responses in
some patients treated with adoptive immunotherapy. Yet many patients experience toxic …

Thoracic malignancies (lung cancers and malignant pleural mesothelioma) are prevalent
worldwide and are associated with high morbidity and mortality. Effective treatments are …

Solid tumors significantly impact global health, necessitating enhanced prevention, early
diagnosis, and treatment approaches. Tumor immunotherapy, notably through programmed …