Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

SLE is characterised by an activation of the interferon (IFN) system, which leads to an
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …

Autoimmune diseases are associated with a dramatically increased risk of atherosclerotic
cardiovascular disease and its clinical manifestations. The increased risk is consistent with …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Neutrophil-specific genes are abundant in PBMC microarrays from lupus patients because
of the presence of low-density granulocytes (LDGs) in mononuclear cell fractions. The …

Recent discoveries have further strengthened the critical role of SLE-related immune
dysregulation and metabolic disturbances in promoting accelerated CVD. Understanding …

Heightened rates of both cardiovascular (CV) events and subclinical atherosclerosis,
documented by imaging and vascular function techniques are well established in systemic …

Systemic lupus erythematosus (SLE) is an autoimmune disease of unclear etiology that
affects mostly women of childbearing age. Profound abnormalities in both innate and …

Tissue regeneration using stem cell-based transplantation faces many hurdles. Alternatively,
therapeutically exploiting endogenous stem cells to regenerate injured or diseased tissue …

Systemic sclerosis, commonly known as scleroderma, is an autoimmune disorder
characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact …