Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease
has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm …

Streptococcus pneumoniae has a complex relationship with its obligate human host. On the
one hand, the pneumococci are highly adapted commensals, and their main reservoir on the …

In addition to physical barriers, neutrophils are considered a part of the first line of immune
defense. They can be found in the bloodstream, with a lifespan of 6–8 h, and in tissue …

Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial
metabolites, our knowledge of their diversity remains limited. Here, we used a novel …

Bacteria are highly interactive and possess an extraordinary repertoire of intercellular
communication and social behaviors, including quorum sensing (QS). QS has been studied …

The microbiota promotes resistance to respiratory infection, but the mechanistic basis for this
is poorly defined. Here, we identify members of the microbiota that protect against …

Respiratory infectious diseases are mainly caused by viruses or bacteria that often interact
with one another. Although their presence is a prerequisite for subsequent infections …

Vaccination with heptavalent pneumococcal conjugate vaccine (PCV7) has significantly
reduced the burden of pneumococcal disease and has had an important public health …