Skin is the body's first barrier against external pathogens that maintains the homeostasis of
the body. Any serious damage to the skin could have an impact on human health and quality …

The mammalian Dok protein family has seven members (Dok‐1–Dok‐7). The Dok proteins
share structural similarities characterized by the NH2‐terminal pleckstrin homology and …

The activation and fusion of macrophages and of osteoclasts require the adaptor molecule
DNAX-activating protein of 12 kD (DAP12), which contains immunoreceptor tyrosine-based …

p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP
bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N …

Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by
increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation …

PURPOSE: The standard treatment of patients with locally advanced rectal cancers
comprises preoperative 5-fluorouracil–based chemoradiotherapy followed by standardized …

Mechanisms underlying the vein development remain largely unknown. Tie2 signaling
mediates endothelial cell (EC) survival and vascular maturation and its activating mutations …

Microglia, the intrinsic neuroimmune cells residing in the central nervous system (CNS),
exert a pivotal influence on brain development, homeostasis, and functionality …

Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein,
that function downstream of a variety of receptor and receptor‐associated tyrosine kinases …

There are several lines of evidence that the podocyte slit diaphragm (SD), which serves as a
structural framework for the filtration barrier in kidney glomerulus, also plays an essential …