Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …

Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Significant advances in mass spectrometry imaging (MSI) have pushed the boundaries in
obtaining spatial information and quantification in biological samples. Quantitative MSI …

Mass spectrometry imaging (MSI) has become a widespread analytical technique to perform
nonlabeled spatial molecular identification. The Achilles' heel of MSI is the annotation and …

A new tissue sample embedding and processing method is presented that provides
downstream compatibility with numerous different histological, molecular biology, and …

Matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI)
permits label-free in situ analysis of chemical compounds directly from the surface of two …

During the last decades, imaging mass spectrometry has gained significant relevance in
biomedical research. Recent advances in imaging mass spectrometry have paved the way …

The concentration and distribution of a drug or its metabolites in tissues are key factors for
understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the …

The potential of mass spectrometry imaging (MSI) has been demonstrated in cell and tissue
research since 1970. MSI can reveal the spatial distribution of a wide range of atomic and …