The kallikrein-related peptidase family: Dysregulation and functions during cancer progression
Cancer is the second leading cause of death with 14 million new cases and 8.2 million
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …
Holding on to junk bonds: intron retention in cancer and therapy
G Monteuuis, U Schmitz, V Petrova, PS Kearney… - Cancer Research, 2021 - AACR
Intron retention (IR) in cancer was for a long time overlooked by the scientific community, as
it was previously considered to be an artifact of a dysfunctional spliceosome. Technological …
it was previously considered to be an artifact of a dysfunctional spliceosome. Technological …
Distribution of 15 human kallikreins in tissues and biological fluids
Abstract Background: Kallikreins (KLKs) are a group of 15 secreted serine proteases. Some
KLKs are established or candidate cancer biomarkers, but for most the physiological …
KLKs are established or candidate cancer biomarkers, but for most the physiological …
Early kidney damage induced by subchronic exposure to PM2.5 in rats
OG Aztatzi-Aguilar, M Uribe-Ramírez… - Particle and fibre …, 2016 - Springer
Background Particulate matter exposure is associated with respiratory and cardiovascular
system dysfunction. Recently, we demonstrated that fine particles, also named PM 2.5 …
system dysfunction. Recently, we demonstrated that fine particles, also named PM 2.5 …
Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
Z Kote-Jarai, A Amin Al Olama, D Leongamornlert… - Human genetics, 2011 - Springer
Genome-wide association studies (GWAS) have identified more than 30 prostate cancer
(PrCa) susceptibility loci. One of these (rs2735839) is located close to a plausible candidate …
(PrCa) susceptibility loci. One of these (rs2735839) is located close to a plausible candidate …
Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron
Perturbation in iron homeostasis is a hallmark of some hematologic diseases. Abnormal
sideroblasts with accumulation of iron in the mitochondria are named ring sideroblasts (RS) …
sideroblasts with accumulation of iron in the mitochondria are named ring sideroblasts (RS) …
Towards the understanding of the human genome: a holistic conceptual modeling approach
Understanding the human genome is a great scientific challenge, whose achievement
requires effective data manipulation mechanisms. The non-stop evolution of both new …
requires effective data manipulation mechanisms. The non-stop evolution of both new …
Intron retention in viruses and cellular genes: Detention, border controls and passports
Intron retention (IR), where one or more introns remain in the RNA after splicing, was long
thought to be rare in mammalian cells, albeit common in plants and some viruses. Largely …
thought to be rare in mammalian cells, albeit common in plants and some viruses. Largely …
Comprehensive splicing functional analysis of DNA variants of the BRCA2 gene by hybrid minigenes
Introduction The underlying pathogenic mechanism of a large fraction of DNA variants of
disease-causing genes is the disruption of the splicing process. We aimed to investigate the …
disease-causing genes is the disruption of the splicing process. We aimed to investigate the …
Clinical significance of human kallikrein 10 gene expression in colorectal cancer and gastric cancer
B Feng, WB Xu, MH Zheng, JJ Ma, Q Cai… - Journal of …, 2006 - Wiley Online Library
Abstract Background and Aim: Recent evidence suggests that the human kallikrein 10
(KLK10) gene is differentially regulated in endocrine‐related tumors and has potential as …
(KLK10) gene is differentially regulated in endocrine‐related tumors and has potential as …