Tools to improve the diagnosis and management of T-cell mediated adverse drug reactions
Delayed drug T-cell immune-mediated hypersensitivity reactions have a large clinical
heterogeneity varying from mild maculopapular exanthema (MPE) to severe cutaneous …
heterogeneity varying from mild maculopapular exanthema (MPE) to severe cutaneous …
Exploring recent advances in drugs severe cutaneous adverse reactions immunopathology
R Cadot, P Gery, V Lenief, JF Nicolas, M Vocanson… - Allergy, 2025 - Wiley Online Library
Severe cutaneous adverse reactions to drugs (SCARs) are rare but life‐threatening delayed
allergies. While they primarily affect the skin, they can also affect internal organs …
allergies. While they primarily affect the skin, they can also affect internal organs …
[HTML][HTML] Systemic and skin-limited delayed-type drug hypersensitivity reactions associate with distinct resident and recruited T cell subsets
Delayed-type drug hypersensitivity reactions are major causes of morbidity and mortality.
The origin, phenotype, and function of pathogenic T cells across the spectrum of severity …
The origin, phenotype, and function of pathogenic T cells across the spectrum of severity …
The roles of immunoregulatory networks in severe drug hypersensitivity
The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have
gained much attention, as they help balance immunogenic and immunotolerant responses …
gained much attention, as they help balance immunogenic and immunotolerant responses …
[HTML][HTML] CD39 transforming cancer therapy by modulating tumor microenvironment
ABSTRACT CD39 is a pivotal enzyme in cancer, regulating immune response and tumor
progression via extracellular ATP and adenosine in the tumor microenvironment (TME) …
progression via extracellular ATP and adenosine in the tumor microenvironment (TME) …
HLA-B* 57: 01/Carbamazepine-10, 11-Epoxide Association Triggers Upregulation of the NFκB and JAK/STAT Pathways
FJ Haukamp, ZM Hartmann, A Pich, J Kuhn, R Blasczyk… - Cells, 2023 - mdpi.com
Measure of drug-mediated immune reactions that are dependent on the patient's genotype
determine individual medication protocols. Despite extensive clinical trials prior to the …
determine individual medication protocols. Despite extensive clinical trials prior to the …
[HTML][HTML] Immunological Mechanisms in Cutaneous Adverse Drug Reactions
AY Lee - Biomolecules & Therapeutics, 2024 - ncbi.nlm.nih.gov
Adverse drug reactions (ADRs) are an inherent aspect of drug use. While approximately
80% of ADRs are predictable, immune system-mediated ADRs, often unpredictable, are a …
80% of ADRs are predictable, immune system-mediated ADRs, often unpredictable, are a …
Diabetes mellitus contributes to carbamazepine resistance in patient with trigeminal neuralgia
Objective To determine whether diabetes mellitus (DM) contributes to the drug resistance of
carbamazepine (CBZ), we investigated the correlation between the blood glucose status …
carbamazepine (CBZ), we investigated the correlation between the blood glucose status …
Anti-epileptic medications
M Maroney, M Markovic - Side effects of drugs annual, 2021 - Elsevier
Abstract Side Effects of Drugs Annual is an annual publication including the most recently
published adverse effects (AEs) and toxicities associated with antiepileptic medications. The …
published adverse effects (AEs) and toxicities associated with antiepileptic medications. The …
[CYTOWANIE][C] Commentary on “The risk of anti‐osteoporotic agent‐induced severe cutaneous adverse drug reactions and their association with HLA” by W‐H Chung …
T Shiohara - Journal of the European Academy of Dermatology …, 2021 - Wiley Online Library
Linked article: C.‐B. Chen et al. J Eur Acad Dermatol Venereol 2021; 35: 712‐720.
https://doi. org/10.1111/jdv. 16924.
https://doi. org/10.1111/jdv. 16924.