The “classical” ovalbumin challenge model of asthma in mice
Ovalbumin challenge models of asthma offer many opportunities for increasing our
understanding of the pathogenetic mechanisms underlying this disease, as well as for …
understanding of the pathogenetic mechanisms underlying this disease, as well as for …
Modeling TH2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma
In this review, we highlight experiments conducted in our laboratories that have elucidated
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …
MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression
Allergic airway inflammation is characterized by marked in situ changes in gene and protein
expression, yet the role of microRNAs (miRNAs), a new family of key mRNA regulatory …
expression, yet the role of microRNAs (miRNAs), a new family of key mRNA regulatory …
IL-9–and mast cell–mediated intestinal permeability predisposes to oral antigen hypersensitivity
EE Forbes, K Groschwitz, JP Abonia… - The Journal of …, 2008 - rupress.org
Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation
and induction of the effector phase of food allergy. However, the mechanism by which …
and induction of the effector phase of food allergy. However, the mechanism by which …
Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review
PD Zalewski, AQ Truong-Tran, D Grosser… - Pharmacology & …, 2005 - Elsevier
In addition to basic housekee** roles in metalloenzymes and transcription factors, dietary
zinc (Zn) is an important immunoregulatory agent, growth cofactor, and cytoprotectant with …
zinc (Zn) is an important immunoregulatory agent, growth cofactor, and cytoprotectant with …
[HTML][HTML] Interleukin-13 signaling and its role in asthma
EL Rael, RF Lockey - World Allergy Organization Journal, 2011 - Elsevier
Asthma affects nearly 300 million people worldwide. The majority respond to inhaled
corticosteroid treatment with or without beta-adrenergic agonists. However, a subset of 5 to …
corticosteroid treatment with or without beta-adrenergic agonists. However, a subset of 5 to …
Cytokine/anti‐cytokine therapy–novel treatments for asthma?
Asthma is a chronic inflammatory disease of the airways and there are no preventions or
cures. Inflammatory cells through the secretion of cytokines and pro‐inflammatory molecules …
cures. Inflammatory cells through the secretion of cytokines and pro‐inflammatory molecules …
Interleukin-4 receptor signaling pathways in asthma pathogenesis
TA Chatila - Trends in molecular medicine, 2004 - cell.com
Asthma is a chronic allergic inflammatory disease, the initiation and progression of which is
dependent on the cytokines interleukin (IL)-4 and IL-13 acting through related receptor …
dependent on the cytokines interleukin (IL)-4 and IL-13 acting through related receptor …
Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target
Background The role of microRNAs (miRNAs) in regulating gene expression is currently an
area of intense interest. Relatively little is known, however, about the role of miRNAs in …
area of intense interest. Relatively little is known, however, about the role of miRNAs in …
Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6
T Liu, H **, M Ullenbruch, B Hu… - The Journal of …, 2004 - journals.aai.org
Found in inflammatory zone (FIZZ) 1, also known as resistin-like molecule α, belongs to a
novel class of cysteine-rich secreted protein family, named FIZZ/resistin-like molecule, with …
novel class of cysteine-rich secreted protein family, named FIZZ/resistin-like molecule, with …