Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an
invaluable drug target for the pharmacological management of pituitary adenomas and …

Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In
cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer …

Background The epidermal growth factor (EGF) stimulates rapid tyrosine phosphorylation of
the EGF receptor (EGFR). This event precedes signaling from both the plasma membrane …

Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical
behavior and require therapies specially tailored according to staging, grading, origin and …

Rationale: CD148/PTRJ (receptor-like protein tyrosine phosphatase η) exerts antifibrotic
effects in experimental pulmonary fibrosis via interactions with its ligand syndecan-2; …

Ptprj is a ubiquitously expressed murine gene encoding a receptor-type protein tyrosine
phosphatase, which has recently been proposed as a candidate gene on the locus Scc1 for …

Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR)
represents one of the main intracellular mechanisms involved in the antiproliferative effect of …

We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta
(ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 …

Background Glioblastoma multiforme (GBM) is a highly lethal, stage IV brain tumour with a
prevalence of approximately 2 per 10,000 people globally. The cell surface proteins or …

The transmembrane protein-tyrosine phosphatase (PTP) DEP-1 (density-enhanced
phosphatase) is a candidate tumor suppressor in the colon epithelium. We have explored …