Traditional shotgun proteomics used to detect a mixture of hundreds to thousands of
proteins through mass spectrometric analysis, has been the standard approach in research …

Optical imaging assays, especially fluorescence molecular assays, are minimally invasive if
not completely noninvasive, and thus an ideal technique to be applied to live specimens …

Advances in fluorescence microscopy have enabled the study of membrane diffusion, cell
adhesion and signal transduction at the molecular level in living cells grown in culture. By …

Cancer cell mutations can be identified by genomic and transcriptomic techniques.
However, they are not sufficient to understand the full complexity of cancer heterogeneity …

Dynamic regulation of specific molecular processes and cellular phenotypes in live cell
systems reveal unique insights into cell fate and drug pharmacology that are not gained from …

The clinical success of trastuzumab in breast cancer taught us that appropriate tumor
evaluation is mandatory for the correct identification of patients eligible for targeted …

The well-oiled machinery of the cellular proteome operates via variable expression,
modifications, and interactions of proteins, relaying genomic and transcriptomic information …

Better biomarkers are urgently needed to cancer detection, diagnosis, and prognosis. While
the genomics community is making significant advances in understanding the molecular …

Background Epidermal growth factor receptor (EGFR) is a therapeutic target to which
HER2/HER3 activation may contribute resistance. This Phase I/II study examined the toxicity …

Protein complex formation has been extensively studied using Förster resonance energy
transfer (FRET) measured by Fluorescence Lifetime Imaging Microscopy (FLIM). However …