Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

The kidney is a mitochondria-rich organ, and kidney diseases are recognized as
mitochondria-related pathologies. Intact mitochondrial DNA (mtDNA) maintains normal …

Objective In this review, we have highlighted advances in genetics, genomics and
epigenetics in the field of osteoarthritis (OA) over the past year. Methods A literature search …

Articular cartilage function depends on the temporal and zonal distribution of coordinated
metabolic regulation in chondrocytes. Emerging evidence shows the importance of cellular …

Osteoarthritis (OA) is an age-associated disease characterized by chronic joint pain
resulting from degradation of articular cartilage, inflammation of the synovial lining, and …

Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic
changes play a key role in the immune response to bacteria, among which DNA …

Objectives Cellular energy metabolism is important for the function of all tissues, including
cartilage. Recent studies indicate that superficial and deep subpopulations of articular …