13C Direct Detected NMR for Challenging Systems
Thanks to recent improvements in NMR spectrometer hardware and pulse sequence design,
modern 13C NMR has become a useful tool for biomolecular applications. The complete …
modern 13C NMR has become a useful tool for biomolecular applications. The complete …
[HTML][HTML] Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics
Water as a good solvent for unfolded proteins: Folding and collapse are fundamentally different
The argument that the hydrophobic effect is the primary effect driving the folding of globular
proteins is nearly universally accepted (including by the authors). But does this view also …
proteins is nearly universally accepted (including by the authors). But does this view also …
Unraveling the molecular interactions involved in phase separation of glucocorticoid receptor
Background Functional compartmentalization has emerged as an important factor
modulating the kinetics and specificity of biochemical reactions in the nucleus, including …
modulating the kinetics and specificity of biochemical reactions in the nucleus, including …
NMR reveals specific tracts within the intrinsically disordered regions of the SARS-CoV-2 nucleocapsid protein involved in RNA encountering
The SARS-CoV-2 nucleocapsid (N) protein is crucial for the highly organized packaging and
transcription of the genomic RNA. Studying atomic details of the role of its intrinsically …
transcription of the genomic RNA. Studying atomic details of the role of its intrinsically …
Characterization of intrinsically disordered regions in proteins informed by human genetic diversity
All proteomes contain both proteins and polypeptide segments that don't form a defined
three-dimensional structure yet are biologically active—called intrinsically disordered …
three-dimensional structure yet are biologically active—called intrinsically disordered …
Commonly used FRET fluorophores promote collapse of an otherwise disordered protein
JA Riback, MA Bowman… - Proceedings of the …, 2019 - National Acad Sciences
The dimensions that unfolded proteins, including intrinsically disordered proteins (IDPs),
adopt in the absence of denaturant remain controversial. We developed an analysis …
adopt in the absence of denaturant remain controversial. We developed an analysis …
The balancing act of intrinsically disordered proteins: enabling functional diversity while minimizing promiscuity
M Macossay-Castillo, G Marvelli, M Guharoy… - Journal of molecular …, 2019 - Elsevier
Intrinsically disordered proteins (IDPs) or regions (IDRs) perform diverse cellular functions,
but are also prone to forming promiscuous and potentially deleterious interactions. We …
but are also prone to forming promiscuous and potentially deleterious interactions. We …
Phasing the intranuclear organization of steroid hormone receptors
Steroid receptors (SRs) encompass a family of transcription factors that regulate the
expression of thousands of genes upon binding to steroid hormones and include the …
expression of thousands of genes upon binding to steroid hormones and include the …