Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which
severely impacts on the global economic development and healthcare system. Though AD …

Background Epilepsy is a common and debilitating consequence of traumatic brain injury
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

Excitotoxic neuronal death, associated with neurodegenerative disorders and hypoxic
insults, results from excessive exposure to excitatory neurotransmitters. Glutamate …

Digital-imaging microfluorimetry of the oxidation of hydroethidine (HEt) to ethidium can be
used to monitor superoxide (O2-) production selectively within individual rat hippocampal …

The HIV-1 envelope protein gp120 induces apoptosis in hippocampal neurons. Because
chemokine receptors act as cellular receptors for HIV-1, we examined rat hippocampal …

The permeability transition pore (PTP) is a channel of the inner mitochondrial membrane
that appears to operate at the crossroads of two distinct physiological pathways, ie, the Ca2+ …

Alzheimer disease (AD) and type 2 diabetes mellitus (T2DM) are conditions that affect a
large number of people in the industrialized countries. Both conditions are on the increase …

Parkinson disease (PD) is a neurodegenerative disorder characterized by dopaminergic
neurons affected by inflammatory processes. Post-mortem analyses of brain and …

Inhibitors of apoptosis (IAPs) are a family of proteins that regulate cell death and
inflammation. XIAP (X-linked IAP) is the only family member that suppresses apoptosis by …