Tegument assembly and secondary envelopment of alphaherpesviruses
Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses …
ability to establish lifelong latent infection in neurons. As for all herpesviruses …
A hitchhiker's guide through the cell: the world according to the capsids of alphaherpesviruses
K Döhner, MC Serrero, A Viejo-Borbolla… - Annual Review of …, 2024 - annualreviews.org
The nucleoplasm, the cytosol, the inside of virions, and again the cytosol comprise the world
in which the capsids of alphaherpesviruses encounter viral and host proteins that support or …
in which the capsids of alphaherpesviruses encounter viral and host proteins that support or …
Spatially resolved protein map of intact human cytomegalovirus virions
B Bogdanow, I Gruska, L Mühlberg, J Protze… - Nature …, 2023 - nature.com
Herpesviruses assemble large enveloped particles that are difficult to characterize
structurally due to their size, fragility and complex multilayered proteome with partially …
structurally due to their size, fragility and complex multilayered proteome with partially …
Molecular plasticity of herpesvirus nuclear egress analysed in situ
V Pražák, Y Mironova, D Vasishtan, C Hagen… - Nature …, 2024 - nature.com
The viral nuclear egress complex (NEC) allows herpesvirus capsids to escape from the
nucleus without compromising the nuclear envelope integrity. The NEC lattice assembles on …
nucleus without compromising the nuclear envelope integrity. The NEC lattice assembles on …
Structural analysis of herpes simplex virus by optical super-resolution imaging
Herpes simplex virus type-1 (HSV-1) is one of the most widespread pathogens among
humans. Although the structure of HSV-1 has been extensively investigated, the precise …
humans. Although the structure of HSV-1 has been extensively investigated, the precise …
Virus assembly and egress of HSV
C Crump - Human herpesviruses, 2018 - Springer
The assembly and egress of herpes simplex virus (HSV) is a complicated multistage process
that involves several different cellular compartments and the activity of many viral and …
that involves several different cellular compartments and the activity of many viral and …
The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion
A hallmark property of the neurotropic alpha-herpesvirinae is the dissemination of infection
to sensory and autonomic ganglia of the peripheral nervous system following an initial …
to sensory and autonomic ganglia of the peripheral nervous system following an initial …
Glycoproteins gE and gI are required for efficient KIF1A-dependent anterograde axonal transport of alphaherpesvirus particles in neurons
Alphaherpesviruses, including pseudorabies virus (PRV), spread directionally within the
nervous systems of their mammalian hosts. Three viral membrane proteins are required for …
nervous systems of their mammalian hosts. Three viral membrane proteins are required for …
Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection
J Quan, Q Fan, LM Simons, SN Smukowski, C Pegg… - MBio, 2024 - journals.asm.org
Neurotropic alphaherpesviruses, including herpes simplex virus type 1 and pseudorabies
virus, establish a lifelong presence within the peripheral nervous system of their mammalian …
virus, establish a lifelong presence within the peripheral nervous system of their mammalian …
The incredible bulk: Human cytomegalovirus tegument architectures uncovered by AI-empowered cryo-EM
The compartmentalization of eukaryotic cells presents considerable challenges to the
herpesvirus life cycle. The herpesvirus tegument, a bulky proteinaceous aggregate …
herpesvirus life cycle. The herpesvirus tegument, a bulky proteinaceous aggregate …