Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral
circadian clocks and obesity. Conversely, restricting feeding to the active period mitigates …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role
in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat …

Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

Obesity increases the risk of mortality because of metabolic sequelae such as type 2
diabetes and cardiovascular disease. Thermogenesis by adipocytes can counteract obesity …