Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …

G protein-coupled receptors (GPCRs) regulate many cellular and physiological processes,
responding to a diverse range of extracellular stimuli including hormones, neurotransmitters …

Cell membrane receptors rarely work on isolation, often they form oligomeric complexes with
other receptor molecules and they may directly interact with different proteins of the signal …

Recent advances in the development of fluorescent ligands for G-protein-coupled receptors
(GPCRs) and receptor tyrosine kinase receptors (RTKs) have facilitated the study of these …

The superfamily of G protein-coupled receptors (GPCRs) mediates a wide range of
physiological responses and serves as an important category of drug targets. Earlier …

In the last three decades, protein and nucleic acid structure determination and
comprehension of the mechanisms, leading to their physiological and pathological …

The fundamental importance of membrane proteins in cellular processes has driven a
marked increase in the use of membrane mimetic approaches for studying and exploiting …

G protein-coupled receptors control a wide range of physiological processes and are the
target for many clinically used drugs. Understanding the way in which receptors bind …

The binding affinity and kinetics of target engagement are fundamental to establishing
structure–activity relationships (SARs) for prospective therapeutic agents. Enhancing these …

G protein-coupled receptors (GPCRs) are organised within the cell membrane into highly
ordered macromolecular complexes along with other receptors and signalling proteins …