Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

Liver fibrosis, a wound‐healing response to a variety of chronic stimuli, is characterized by
excessive deposition of extracellular matrix (ECM) proteins, of which type I collagen …

The development of 3D in vitro models capable of recapitulating native tumor
microenvironments could improve the translatability of potential anticancer drugs and …

Although ribonuclease H activity has long been implicated as a molecular mechanism by
which DNA-like oligonucleotides induce degradation of target RNAs, definitive proof that …

Recruitment to activated tyrosine kinase growth factor receptors of Grb2 and p21ras leads to
downstream activation of the kinases Raf, MAPK/Erk kinase (Mek) and, subsequently …

Following a fibrogenic stimulus, the hepatic stellate cell (HSC) undergoes a complex
activation process associated with increased cell proliferation and excess deposition of type …

[Frontiers in Bioscience 8, d69-77, January 1, 2003] 69 LIVER FIBROSIS: SIGNALS LEADING
TO THE AMPLIFICATION OF THE FIBROGENIC H Page 1 [Frontiers in Bioscience 8, d69-77 …

Abstract Δ 9-Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has
been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and …

The impaired regenerative capacity of fatty livers might promote the progression of
nonalcoholic fatty liver disease (NAFLD). To identify mechanisms involved, regenerative …

While transport of RNA-binding protein HuR from nucleus to cytoplasm is emerging as a key
regulatory step for HuR function, the mechanisms underlying this process remain poorly …