Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …

Background Liver cancer ranks the top four malignant cancer type worldwide, which needs
effective and safe treatment. Ferroptosis is a novel form of regulated cell death driven by iron …

Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …

Ketamine was introduced into clinical practice in the 1960s and continues to be both
clinically useful and scientifically fascinating. With considerably diverse molecular targets …

Ketamine and its enantiomer S-ketamine (esketamine) are promising candidates to produce
a rapid-onset antidepressant effect in treatment-resistant depression. Ketamine causes …

The anaesthetic ketamine is used to treat various chronic pain syndromes, especially those
that have a neuropathic component. Low dose ketamine produces strong analgesia in …

Delusions are the false and often incorrigible beliefs that can cause severe suffering in
mental illness. We cannot yet explain them in terms of underlying neurobiological …

Is there a theory that explains the essence of consciousness? Or is consciousness itself an
illusion? Am I conscious now? Now considered the'last great mystery of science' …

Introduction Various experimental manipulations, usually involving drug administration,
have been used to produce symptoms of psychosis in healthy volunteers. Different drugs …