Objective: To attempt to determine the relative value of preclinical cardiac electrophysiology
data (in vitro and in vivo) for predicting risk of torsade de pointes (TdP) in clinical use …

This review addresses novel concepts of histamine H1‐receptor function and attempts to
relate them to the anti‐inflammatory effects of H1‐antihistamines. Furthermore, the …

Covering: up to the end of 2005Saxitoxin (STX) was discovered early last century and can
contaminate seafood and drinking water, and over time has become an invaluable research …

Computer-aided drug design (CADD) often involves virtual screening (VS) of large
compound datasets and the availability of such is vital for drug discovery protocols. We …

In this paper, we present a pharmacophore for QT-prolonging drugs, along with a 3D QSAR
(CoMFA) study for a series of very structurally variegate HERG K+ channel blockers. The …

Natural products (NPs) are often regarded as sources of drugs or drug leads or simply as a
“source of inspiration” for the discovery of novel drugs. We have built the Northern African …

The human ether-a-gogo–related gene (hERG) encodes the α subunit of the cardiac
potassium current I Kr. Several mutations in hERG produce trafficking-deficient channels that …

Target-and ligand-based virtual screening have emerged as resource-saving techniques
that have been successfully applied to identify novel chemotypes in biologically active …

Prolongation of the QT interval of the electrocardiogram is a typical effect of Class III
antiarrhythmic drugs, achieved through blockade of potassium channels. In the past decade …

Drug-induced torsades de pointes (TdP) arrhythmia is a major safety concern in the process
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …