Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023 - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

Effect of coronaviruses on blood vessel permeability: potential therapeutic targets

NR Machado, KT Dias, BFS Cortes… - Therapeutic …, 2023 - journals.sagepub.com
Coronavirus-induced diseases have afflicted humanity for several decades. This scenario
was aggravated by the emergence of the coronavirus disease 2019 (named COVID-19) in …

Antimicrobial Resistance in Pseudomonas aeruginosa before and during the COVID-19 Pandemic

E Serretiello, R Manente, F Dell'Annunziata, V Folliero… - Microorganisms, 2023 - mdpi.com
Pseudomonas aeruginosa (PA) is a major Gram-negative opportunistic pathogen causing
several serious acute and chronic infections in the nosocomial and community settings. PA …

Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NF-κB/MAPK/JNK Signaling Pathway in …

OF Fagbohun, WPDW Thilakarathna, J Zhou… - Molecules, 2024 - mdpi.com
Acute lung injury (ALI) represents a life-threatening condition with high morbidity and
mortality despite modern mechanical ventilators and multiple pharmacological strategies …

An anticomplement homogeneous polysaccharide from Hedyotis diffusa attenuates lipopolysaccharide-induced acute lung injury and inhibits neutrophil extracellular …

J Zhang, J Huo, Z Zhao, Y Lu, Z Hong, H Li, D Chen - Phytomedicine, 2022 - Elsevier
Background Owing to the involvement of the overactivated complement system in acute lung
injury (ALI) development, anticomplement components may attenuate ALI. Hedyotis diffusa …

[HTML][HTML] KVX-053, a protein tyrosine phosphatase 4A3 inhibitor, ameliorates SARS-CoV-2 spike protein subunit 1–induced acute lung injury in mice

PA Solopov, RMLC Biancatelli, T Day, B Gregory… - The Journal of …, 2025 - Elsevier
Acute respiratory distress syndrome (ARDS), often preceded by acute lung injury (ALI), is
characterized by the accumulation of inflammatory fluid in the lung alveoli, leaky alveolar …

Food-derived antioxidants intake association with serum oxidative stress markers and lung infection symptoms in COVID-19 infectious angina patients

M Mohajeri, B Aghapoor - Nutrition & Food Science, 2024 - emerald.com
Purpose Research indicated that dietary antioxidants could improve immune system
performance. This study aims to investigate the association of COVID-19 symptoms, total …

Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice

K Yamamoto, H Watanabe‐Takano… - The FASEB …, 2023 - Wiley Online Library
Vascular permeability is dynamically but tightly controlled by vascular endothelial (VE)‐
cadherin‐mediated endothelial cell–cell junctions to maintain homeostasis. Thus …

Nebulized recombinant tissue plasminogen activator (rt-PA) for acute COVID-19-induced respiratory failure: an exploratory proof-of-concept trial

P Chowdary, B Agarwal, MR Peralta… - Journal of Clinical …, 2023 - mdpi.com
Acute lung injury in COVID-19 results in diffuse alveolar damage with disruption of the
alveolar-capillary barrier, coagulation activation, alveolar fibrin deposition and pulmonary …

Therapeutic potential of proteases in acute lung injury and respiratory distress syndrome via TLR4/Nrf2/NF-kB signaling modulation

HM Anwar, GEM Salem, HM Abd El-Latief… - International Journal of …, 2024 - Elsevier
The COVID-19 pandemic has drawn attention to acute lung injury and respiratory distress
syndrome as major causes of death, underscoring the urgent need for effective treatments …