Dendritic cells in cancer immunology

TL Murphy, KM Murphy - Cellular & molecular immunology, 2022 - nature.com
The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

Dendritic cells revisited

M Cabeza-Cabrerizo, A Cardoso… - Annual review of …, 2021 - annualreviews.org
Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, sha** adaptive and innate immunity. Over the years, a …

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

SA Dick, A Wong, H Hamidzada, S Nejat… - Science …, 2022 - science.org
Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is
appreciated that different tissues instruct specialized macrophage functions. However …

[HTML][HTML] Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

K Mulder, AA Patel, WT Kong, C Piot, E Halitzki… - Immunity, 2021 - cell.com
Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …

[HTML][HTML] Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors

Z Liu, H Wang, Z Li, RJ Dress, Y Zhu, S Zhang… - Immunity, 2023 - cell.com
Conventional dendritic cells (cDCs) are professional antigen-presenting cells that control the
adaptive immune response. Their subsets and developmental origins have been intensively …

[HTML][HTML] Transcriptional basis of mouse and human dendritic cell heterogeneity

CC Brown, H Gudjonson, Y Pritykin, D Deep… - Cell, 2019 - cell.com
Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …

Origin and heterogeneity of tissue myeloid cells: a focus on GMP-derived monocytes and neutrophils

LG Ng, Z Liu, I Kwok, F Ginhoux - Annual Review of …, 2023 - annualreviews.org
Myeloid cells are a significant proportion of leukocytes within tissues, comprising
granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various …

Trial watch: Dendritic cell (DC)-based immunotherapy for cancer

RS Laureano, J Sprooten, I Vanmeerbeerk… - …, 2022 - Taylor & Francis
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

[HTML][HTML] Progenitors of distinct lineages shape the diversity of mature type 2 conventional dendritic cells

PF Rodrigues, T Trsan, G Cvijetic, D Khantakova… - Immunity, 2024 - cell.com
Conventional dendritic cells (cDC) are antigen-presenting cells comprising cDC1 and cDC2,
responsible for priming naive CD8+ and CD4+ T cells, respectively. Recent studies have …