BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …

Bromodomain-containing protein 4 (Brd4) plays an important role in mediating the
expression of genes involved in cancers and non-cancer diseases such as inflammatory …

Proteins of the bromodomain and extra-terminal (BET) family are epigenetics “readers” and
promising therapeutic targets for cancer and other human diseases. We describe herein a …

A cobalt-catalyzed C–H carbonylation of naphthylamides for the synthesis of benzo [cd]
indol-2 (1 H)-one scaffolds has been developed. The reaction employs a traceless directing …

Indole alkaloids have attracted widespread attention of chemists and biologists. Therefore,
the aim of this study is to screen more bioactivities indole alkaloids from the microorganisms …

Introduction: Docking and structure-based virtual screening (VS) have been standard
approaches in structure-based design for over two decades. However, our understanding of …

The bromodomain and extra-terminal domain (BET) family of proteins are readers which
specifically recognize histone-acetylated lysine residues. Each BET bromodomain protein …

Epigenetic dysfunction has been widely implicated in several diseases especially cancers
thus highlights the therapeutic potential for chemical interventions in this field. With rapid …

The transcriptional coactivator cAMP response element binding protein (CREB)-binding
protein (CBP) and its homologue p300 have emerged as attractive therapeutic targets for …

The bromodomain and extra-terminal (BET) family proteins have gained increasing interest
as drug targets for treatment of castration-resistant prostate cancer (CRPC). Here, we …