Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease
Z Liu, RA Khalil - Biochemical pharmacology, 2018 - Elsevier
Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …
Identifying the mechanisms of VSM contraction has been a major research goal in order to …
NFAT pulls the strings during CD4+ T helper cell effector functions
The Ca2+ dependent transcription factor family known as nuclear factor of activated T cells
(NFAT) has been shown to be important in T-cell immune responses. Because NFAT …
(NFAT) has been shown to be important in T-cell immune responses. Because NFAT …
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Genome-wide association studies (GWASs) have identified hundreds of susceptibility
genes, including shared associations across clinically distinct autoimmune diseases. We …
genes, including shared associations across clinically distinct autoimmune diseases. We …
HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells
MF Santos, G Rappa, J Karbanová, P Diana… - Nature …, 2023 - nature.com
The mechanism of human immunodeficiency virus 1 (HIV-1) nuclear entry, required for
productive infection, is not fully understood. Here, we report that in HeLa cells and activated …
productive infection, is not fully understood. Here, we report that in HeLa cells and activated …
Protein kinase C pharmacology: refining the toolbox
AX Wu-Zhang, AC Newton - Biochemical Journal, 2013 - portlandpress.com
PKC (protein kinase C) has been in the limelight since the discovery three decades ago that
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …
Response to Bruton's tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
Diffuse large B cell lymphoma (DLBCL) is an aggressive, profoundly heterogeneous cancer,
presenting a challenge for precision medicine. Bruton's tyrosine kinase (BTK) inhibitors …
presenting a challenge for precision medicine. Bruton's tyrosine kinase (BTK) inhibitors …
The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers
Overexpression of the antiviral DNA cytosine deaminase APOBEC3B has been linked to
somatic mutagenesis in many cancers. Human papillomavirus infection accounts for …
somatic mutagenesis in many cancers. Human papillomavirus infection accounts for …
GNAQ and GNA11 mutations in uveal melanoma
G-protein-coupled receptors signal through heterotrimeric G proteins, Gα and G-βγ, to
manage numerous aspects of physiologic homeostasis. Many neoplastic processes harbor …
manage numerous aspects of physiologic homeostasis. Many neoplastic processes harbor …
Protein kinase C as regulator of vascular smooth muscle function and potential target in vascular disorders
HC Ringvold, RA Khalil - Advances in pharmacology, 2017 - Elsevier
Vascular smooth muscle (VSM) plays an important role in maintaining vascular tone. In
addition to Ca 2+-dependent myosin light chain (MLC) phosphorylation, protein kinase C …
addition to Ca 2+-dependent myosin light chain (MLC) phosphorylation, protein kinase C …
The dual roles of the atypical protein kinase Cs in cancer
Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered
fundamental regulators of tumorigenesis. However, the specific separation of functions that …
fundamental regulators of tumorigenesis. However, the specific separation of functions that …