A molecular mechanism of aluminium-induced Alzheimer's disease?

C Exley - Journal of inorganic biochemistry, 1999 - Elsevier
An abundance of research has continued to link aluminium (Al) with Alzheimer's disease
(AD)(Strong et al., J. Toxicol. Environ. Health 48 (1996) 599; Savory et al., J. Toxicol …

Chronic aluminum intake causes Alzheimer's disease: applying Sir Austin Bradford Hill's causality criteria

JR Walton - Journal of Alzheimer's Disease, 2014 - content.iospress.com
Industrialized societies produce many convenience foods with aluminum additives that
enhance various food properties and use alum (aluminum sulfate or aluminum potassium …

Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats

A Kumar, S Dogra, A Prakash - Behavioural brain research, 2009 - Elsevier
Aluminium is a potent neurotoxin and has been associated with Alzheimer's disease (AD)
causality for decades. Prolonged aluminium exposure induces oxidative stress and …

Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence

B Platt, G Fiddler, G Riedel, Z Henderson - Brain research bulletin, 2001 - Elsevier
Although the neurotoxic actions of aluminium (Al) have been well documented, its
contribution to neurodegenerative diseases such as Alzheimer's disease remains …

Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

AV Skalny, M Aschner, Y Jiang, YG Gluhcheva… - Advances in …, 2021 - Elsevier
Recent studies have demonstrated that brain may be considered as the target for aluminium
(Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental …

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity

G Crépeaux, H Eidi, MO David, Y Baba-Amer… - Toxicology, 2017 - Elsevier
Abstract Aluminium (Al) oxyhydroxide (Alhydrogel®), the main adjuvant licensed for human
and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate …

Modulatory role of simvastatin against aluminium chloride‐induced behavioural and biochemical changes in rats

M Nampoothiri, J John, N Kumar, J Mudgal… - Behavioural …, 2015 - Wiley Online Library
Objectives. Aluminium, a neurotoxic agent in humans, has been implicated in the
pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral …

Acetylcholinesterase activation and enhanced lipid peroxidation after long-term exposure to low levels of aluminum on different mouse brain regions

RR Kaizer, MC Corrêa, RM Spanevello… - Journal of inorganic …, 2005 - Elsevier
Aluminum (Al), oxidative stress and impaired cholinergic functions have all been related to
Alzheimer's disease (AD). The present study evaluates the effect of aluminum on …

In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase

P Zatta, M Ibn-Lkhayat-Idrissi, P Zambenedetti… - Brain research …, 2002 - Elsevier
Cholinesterases are a large family of enzymatic proteins widely distributed throughout both
neuronal and non-neuronal tissues. In Alzheimer's disease (AD), analytical as well as …

Neuroprotective effect of carvedilol against aluminium induced toxicity: possible behavioral and biochemical alterations in rats

A Kumar, A Prakash, S Dogra - Pharmacological Reports, 2011 - Springer
Aluminium, is a trace element available in the Earth's crust naturally and has a toxic potential
for humans. It has been suggested as a contributing factor in the pathogenesis of …