Knee osteoarthritis (KOA) is a common chronic articular disease worldwide. It is also the
most common form of OA and is characterized by high morbidity and disability rates. With the …

Osteoarthritis (OA) is an age-related disease, characterized by cartilage degeneration. The
pathogenesis of OA is complicated and the current therapeutic approaches for OA are …

Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA),
but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections …

Regulating macrophage activation precisely is crucial in treating chronic inflammation in
osteoarthritis (OA). However, the stable pro-inflammatory state and deep distribution of …

The musculoskeletal system supports the movement of the entire body and provides blood
production while acting as an endocrine organ. With aging, the balance of bone …

The emerging therapeutic strategies for osteoarthritis (OA) are shifting toward
comprehensive approaches that target periarticular tissues, involving both cartilage and …

Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Abnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint
dysplasia and osteoarthritis (OA); However, the clinical translation of FGF18‐based protein …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …