It is well established that oxidative stress is an important cause of cell damage associated
with the initiation and progression of many diseases. Consequently, all air-living organisms …

Following the discovery of protein modification by the small, highly conserved ubiquitin
polypeptide, a number of distinct ubiquitin-like proteins (Ubls) have been found to function …

Faithful genome integrity maintenance plays an essential role in cell survival. Here, we
identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA …

The demands of structural and functional genomics for large quantities of soluble, properly
folded proteins in heterologous hosts have been aided by advancements in the field of …

The eukaryotic ubiquitin family encompasses nearly 20 proteins that are involved in the
posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) …

Covalent histone post-translational modifications such as acetylation, methylation,
phosphorylation, and ubiquitylation play pivotal roles in regulating many cellular processes …

Posttranslational modification with small ubiquitin-related modifier (SUMO) has emerged as
a central regulatory mechanism of protein function. However, little is known about the …

SIRT1 is the closest mammalian homologue of yeast SIR2, an important ageing regulator
that prolongs lifespan in response to caloric restriction. Despite its importance, the …

The small ubiquitin-like modifier (SUMO) family in vertebrates includes three different family
members that are conjugated as post-translational modifications to target proteins. SUMO-2 …

Protein sumoylation is an important reversible post‐translational modification on proteins,
and orchestrates a variety of cellular processes. Recently, computational prediction of …