Historically, the interlacing of strands at the molecular level has mainly been limited to
coordination polymers and DNA. Despite being proposed on a number of occasions, the …

In recent years, applications and experimental studies of DNA in nanochannels have
stimulated the investigation of the polymer physics of DNA in confinement. Recent advances …

Long DNA molecules can self-entangle into knots. Experimental techniques for observing
such DNA knots (primarily gel electrophoresis) are limited to bulk methods and circular …

Equilibrium knots are common in biological polymers—their prevalence, size distribution,
structure, and dynamics have been extensively studied, with implications to fundamental …

Macromolecules can gain special properties by adopting knotted conformations, but
engineering knotted macromolecules is a challenging task. Here, we unexpectedly find that …

The variation of polymer topology provides an alternative way to tune the properties of
polymer materials without varying the chemistry of the monomers composing the polymer …

We use an accurate coarse-grained model for DNA and stochastic molecular dynamics
simulations to study the pore translocation of 10-kbp–long DNA rings that are knotted. By …

Knots form when polymers self-entangle, a process enhanced by compaction with important
implications in biological and artificial systems involving chain confinement. In particular …

Knots in DNA occur in biological systems, serve as a model system for polymer
entanglement, and affect the efficacy of modern genomics technologies. We study the …

We study the diffusion of knots along relaxed deoxyribonucleic acid (DNA) in nanochannels
using a nanofluidic “knot factory” device for knot generation. The apparent scaling exponent …