Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …

Collective cell migration underlies morphogenesis, wound healing and cancer invasion,.
Most directed migration in vivo has been attributed to chemotaxis, whereby cells follow a …

Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell
and progenitor cell populations. One example is the deterioration of the regenerative …