Structural and chemical biology of terpenoid cyclases

DW Christianson - Chemical reviews, 2017 - ACS Publications
The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Decoding catalysis by terpene synthases

JN Whitehead, NGH Leferink, LO Johannissen… - ACS …, 2023 - ACS Publications
The review by Christianson, published in 2017 on the twentieth anniversary of the
emergence of the field, summarizes the foundational discoveries and key advances in …

Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity

PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Biosynthesis and biological functions of terpenoids in plants

D Tholl - Biotechnology of isoprenoids, 2015 - Springer
<? xm-replace_text {Heading}?> Abstract Terpenoids (isoprenoids) represent the largest
and most diverse class of chemicals among the myriad compounds produced by plants …

Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids

S Dusséaux, WT Wajn, Y Liu, C Ignea… - Proceedings of the …, 2020 - pnas.org
Current approaches for the production of high-value compounds in microorganisms mostly
use the cytosol as a general reaction vessel. However, competing pathways and metabolic …

Oleoresin defenses in conifers: chemical diversity, terpene synthases and limitations of oleoresin defense under climate change

JM Celedon, J Bohlmann - New Phytologist, 2019 - Wiley Online Library
Conifers have evolved complex oleoresin terpene defenses against herbivores and
pathogens. In co‐evolved bark beetles, conifer terpenes also serve chemo‐ecological …

The family of terpene synthases in plants: a mid‐size family of genes for specialized metabolism that is highly diversified throughout the kingdom

F Chen, D Tholl, J Bohlmann, E Pichersky - The Plant Journal, 2011 - Wiley Online Library
Some plant terpenes such as sterols and carotenes are part of primary metabolism and
found essentially in all plants. However, the majority of the terpenes found in plants are …

Bacterial terpene cyclases

JS Dickschat - Natural product reports, 2016 - pubs.rsc.org
Covering: up to 2015 This review summarises the accumulated knowledge about
characterised bacterial terpene cyclases. The structures of identified products and of …

Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications

B Singh, RA Sharma - 3 Biotech, 2015 - Springer
The terpenoids constitute the largest class of natural products and many interesting products
are extensively applied in the industrial sector as flavors, fragrances, spices and are also …

Explaining intraspecific diversity in plant secondary metabolites in an ecological context

BD Moore, RL Andrew, C Külheim, WJ Foley - New Phytologist, 2014 - Wiley Online Library
Plant secondary metabolites (PSM s) are ubiquitous in plants and play many ecological
roles. Each compound can vary in presence and/or quantity, and the composition of the …