The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the
modulation of neuronal excitability, and a disruption of GABAergic transmission contributes …

Background The possibility that onchocerciasis may cause epilepsy has been suggested for
a long time, but thus far, an etiological link has not been universally accepted. The objective …

Background Nodding syndrome is a poorly understood neurological disorder that
predominantly occurs in Africa. We hypothesised that nodding syndrome is a …

There are only a few drugs that can seriously lay claim to the title of “wonder drug,” and
ivermectin, the world's first endectocide and forerunner of a completely new class of …

This narrative review intends to inform neurologists and public health professionals about
Onchocerciasis-Associated Epilepsy (OAE), a neglected public health problem in many …

Twenty diseases are recognized as neglected tropical diseases (NTDs) by World Health
Assembly resolutions, including human filarial diseases. The end of NTDs is embedded …

Nodding syndrome has been suggested to be triggered by neurotoxic leiomodin-1 auto-
antibodies cross-reacting with Onchocerca volvulus. Here, we screened serum and CSF …

Purpose To document epilepsy-related mortality in sub-Saharan Africa (SSA) and
investigate possible associations with onchocerciasis endemicity. Methods Systematic …

Introduction Ivermectin (IVM) is an antiparasitic medicine that exerts its function through
glutamate-gated chloride channels and GABA A receptors predominantly. There is paucity of …

Onchocerciasis is diagnosed by detecting microfilariae in skin snips or by detecting OV16
IgG4 antibodies in blood by either enzyme linked immunosorbent assay (ELISA) or a rapid …