Bio-inspired hemocompatible surface modifications for biomedical applications

M Douglass, M Garren, R Devine, A Mondal… - Progress in materials …, 2022 - Elsevier
When blood first encounters the artificial surface of a medical device, a complex series of
biochemical reactions is triggered, potentially resulting in clinical complications such as …

COVID-19 and thrombosis: The role of hemodynamics

S Sastry, F Cuomo, J Muthusamy - Thrombosis research, 2022 - Elsevier
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by an increased risk
of thromboembolic events, a leading cause for adverse outcomes in patients afflicted by the …

Platelets and extra-corporeal membrane oxygenation in adult patients: a systematic review and meta-analysis

F Jiritano, GF Serraino, H Ten Cate, D Fina… - Intensive care …, 2020 - Springer
Despite increasing improvement in extracorporeal membrane oxygenation (ECMO)
technology and knowledge, thrombocytopenia and impaired platelet function are usual …

[HTML][HTML] Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI

P Lukito, A Wong, J **g, JF Arthur, SF Marasco… - Journal of Thrombosis …, 2016 - Elsevier
Essentials• Relationship of acquired von Willebrand disease (VWD) and platelet dysfunction
is explored.• Patients with ventricular assist devices and on extracorporeal membrane …

[HTML][HTML] Hematologic concerns in extracorporeal membrane oxygenation

J Sniderman, P Monagle, GM Annich… - Research and Practice in …, 2020 - Elsevier
This ISTH “State of the Art” review aims to critically evaluate the hematologic considerations
and complications in extracorporeal membrane oxygenation (ECMO). ECMO is …

Investigation of the influence of blade configuration on the hemodynamic performance and blood damage of the centrifugal blood pump

Y Li, J Yu, H Wang, Y **, X Deng, Z Chen… - Artificial …, 2022 - Wiley Online Library
Purpose The design and optimization of centrifugal blood pumps are crucial for improved
extracorporeal membrane oxygenation system performance. Secondary flow passages are …

Computational characterization of flow and blood damage potential of the new maglev CH-VAD pump versus the HVAD and HeartMate II pumps

J Zhang, Z Chen, BP Griffith… - The International journal …, 2020 - journals.sagepub.com
Left ventricular assist devices are routinely used to treat patients with advanced heart failure
as a bridge to transplant or a destination therapy. However, non-physiological shear stress …

Flow features and device‐induced blood trauma in CF‐VADs under a pulsatile blood flow condition: a CFD comparative study

Z Chen, SK Jena, GA Giridharan… - … journal for numerical …, 2018 - Wiley Online Library
In this study, the flow features and device‐associated blood trauma in 4 clinical ventricular
assist devices (VADs; 2 implantable axial VADs, 1 implantable centrifugal VAD, and 1 …

High shear induces platelet dysfunction leading to enhanced thrombotic propensity and diminished hemostatic capacity

Z Chen, NK Mondal, S Zheng, SC Koenig… - Platelets, 2019 - Taylor & Francis
Thrombosis and bleeding are devastating adverse events in patients supported with blood-
contacting medical devices (BCMDs). In this study, we delineated that high non …

A new mathematical numerical model to evaluate the risk of thrombosis in three clinical ventricular assist devices

Y Li, H Wang, Y **, A Sun, X Deng, Z Chen, Y Fan - Bioengineering, 2022 - mdpi.com
(1) Background: Thrombosis is the main complication in patients supported with ventricular
assist devices (VAD). Models that accurately predict the risk of thrombus formation in VADs …