Primary aldosteronism (PA) is an endocrinopathy characterized by dysregulated
aldosterone production that occurs despite suppression of renin and angiotensin II, and that …

The variety of taste sensations, including sweet, umami, bitter, sour, and salty, arises from
diverse taste cells, each of which expresses specific taste sensor molecules and associated …

The location of neurons generating the rhythm of breathing in mammals is unknown. By
microsection of the neonatal rat brainstem in vitro, a limited region of the ventral medulla (the …

Sodium taste regulates salt intake. The amiloride-sensitive epithelial sodium channel
(ENaC) is the Na+ sensor in taste cells mediating attraction to sodium salts. However, cells …

Salt taste in mammals can trigger two divergent behavioural responses. In general,
concentrated saline solutions elicit robust behavioural aversion, whereas low concentrations …

The apical (outward-facing) membranes of high-resistance epithelia contain Na+ channels,
traditionally identified by their sensitivity to block by the K (+)-sparing diuretic amiloride …

Recent research on cellular mechanisms of peripheral taste has defined transduction
pathways involving membrane receptors, G proteins, second messengers, and ion …

Salt taste, the taste of sodium chloride (NaCl), is mechanistically one of the most complex
and puzzling among basic tastes. Sodium has essential functions in the body but causes …

A novel G protein α-subunit (α-gustducin) has been identified and cloned from taste tissue, α-
Gustducin messenger RNA is expressed in taste buds of all taste papillae (circumvallate …

Saliva is the principal fluid component of the external environment of the taste receptor cells
and, as such, could play a role in taste sensitivity. Its main role includes transport of taste …