Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
[HTML][HTML] Engineering CAR-T cells for next-generation cancer therapy
T cells engineered to express chimeric antigen receptors (CARs) with tumor specificity have
shown remarkable success in treating patients with hematologic malignancies and …
shown remarkable success in treating patients with hematologic malignancies and …
A human circulating immune cell landscape in aging and COVID-19
Y Zheng, X Liu, W Le, L **e, H Li, W Wen, S Wang… - Protein & …, 2020 - academic.oup.com
Age-associated changes in immune cells have been linked to an increased risk for infection.
However, a global and detailed characterization of the changes that human circulating …
However, a global and detailed characterization of the changes that human circulating …
The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
Next-generation stem cells—ushering in a new era of cell-based therapies
Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …
decades. This has primarily involved the transplantation of primary cells such as …
Genetic engineering of T cells for immunotherapy
Genetically engineered T cell immunotherapies have provided remarkable clinical success
to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill …
to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill …
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1)
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …
Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo
An effective strategy to cure HIV will likely require a potent and sustained antiviral T cell
response. Here we explored the utility of chimeric antigen receptor (CAR) T cells, expressing …
response. Here we explored the utility of chimeric antigen receptor (CAR) T cells, expressing …
Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment
Cerebral malaria (CM) caused by Plasmodium falciparum is a fatal neurological
complication of malaria, resulting in coma and death, and even survivors may suffer long …
complication of malaria, resulting in coma and death, and even survivors may suffer long …
Unique challenges for glioblastoma immunotherapy—discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report …
Cancer immunotherapy has made remarkable advances with over 50 separate Food and
Drug Administration (FDA) approvals as first-or second-line indications since 2015. These …
Drug Administration (FDA) approvals as first-or second-line indications since 2015. These …