Cardiac excitation–contraction coupling
DM Bers - Nature, 2002 - nature.com
Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the
most important. It is crucial to the very process that enables the chambers of the heart to …
most important. It is crucial to the very process that enables the chambers of the heart to …
Calcium fluxes involved in control of cardiac myocyte contraction
DM Bers - Circulation research, 2000 - Am Heart Assoc
Intracellular Ca2 is the central regulator of cardiac contrac-tility. Moreover, it is becoming
increasingly apparent that alterations in myocyte Ca2 regulation may be critically important …
increasingly apparent that alterations in myocyte Ca2 regulation may be critically important …
[BOOK][B] Excitation-contraction coupling and cardiac contractile force
D Bers - 2001 - books.google.com
How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …
What are the links between cardiac structure and function? How does our understanding of …
Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual β-adrenergic …
SM Pogwizd, K Schlotthauer, L Li, W Yuan… - Circulation …, 2001 - Am Heart Assoc
Ventricular arrhythmias and contractile dysfunction are the main causes of death in human
heart failure (HF). In a rabbit HF model reproducing these same aspects of human HF, we …
heart failure (HF). In a rabbit HF model reproducing these same aspects of human HF, we …
Cellular basis of abnormal calcium transients of failing human ventricular myocytes
Depressed contractility is a central feature of the failing human heart and has been attributed
to altered [Ca2+] i. This study examined the respective roles of the L-type Ca2+ current (I …
to altered [Ca2+] i. This study examined the respective roles of the L-type Ca2+ current (I …
Sodium-calcium exchange: a molecular perspective
KD Philipson, DA Nicoll - Annual review of physiology, 2000 - annualreviews.org
▪ Abstract Plasma membrane Na+-Ca2+ exchange is an essential component of Ca2+
signaling pathways in several tissues. Activity is especially high in the heart where the …
signaling pathways in several tissues. Activity is especially high in the heart where the …
Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release
There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR)
membrane in cardiac myocytes. The relationship between channel structure, associated …
membrane in cardiac myocytes. The relationship between channel structure, associated …
An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release
The local control theory of excitation-contraction (EC) coupling in cardiac muscle asserts that
L-type Ca 2+ current tightly controls Ca 2+ release from the sarcoplasmic reticulum (SR) via …
L-type Ca 2+ current tightly controls Ca 2+ release from the sarcoplasmic reticulum (SR) via …
Modulation of excitation–contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger
KS Ginsburg, DM Bers - The Journal of physiology, 2004 - Wiley Online Library
Cardiac Ca2+ transients are enhanced by cAMP‐dependent protein kinase (PKA). However,
PKA‐dependent modulation of ryanodine receptor (RyR) function in intact cells is difficult to …
PKA‐dependent modulation of ryanodine receptor (RyR) function in intact cells is difficult to …
Chasing cardiac physiology and pathology down the CaMKII cascade
Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-
contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the …
contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the …