Human activities are accelerating rates of biological invasions and climate-driven range
expansions globally, yet we understand little of how genomic processes facilitate the …

Long-read de novo genome assembly continues to advance rapidly. However, there is a
lack of effective tools to accurately evaluate the assembly results, especially for structural …

The domestic cat (Felis catus) numbers over 94 million in the USA alone, occupies
households as a companion animal, and, like humans, suffers from cancer and common and …

Resolving genomes at haplotype level is crucial for understanding the evolutionary history of
polyploid species and for designing advanced breeding strategies. Polyploid phasing still …

Background Structural variation (SV) acts as an essential mutational force sha** the
evolution and function of the human genome. However, few studies have examined the role …

Genetic maps have been fundamental to building our understanding of disease genetics
and evolutionary processes. The gametes of an individual contain all of the information …

Background SNP arrays, short-and long-read genome sequencing are genome-wide high-
throughput technologies that may be used to assay copy number variants (CNVs) in a …

A substantial fraction of the human genome is difficult to interrogate with short-read DNA
sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats …

Background Genomic structural variations (SV) are important determinants of genotypic and
phenotypic changes in many organisms. However, the detection of SV from next-generation …

Previous studies have surveyed the potential impact of loss-of-function (LoF) variants and
identified LoF-tolerant protein-coding genes. However, the tolerance of human genomes to …