Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer
H Zhang, C Qin, C An, X Zheng, S Wen, W Chen, X Liu… - Molecular cancer, 2021 - Springer
Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …
Jennifer Doudna for the development of the Clustered regularly interspaced short …
[HTML][HTML] Advances in CRISPR therapeutics
The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
[HTML][HTML] Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …
CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …
research era. Genome modification studies have traveled a long way from gene …
CRISPR/Cas9-mediated viral interference in plants
Abstract Background The CRISPR/Cas9 system provides bacteria and archaea with
molecular immunity against invading phages and conjugative plasmids. Recently …
molecular immunity against invading phages and conjugative plasmids. Recently …
CRISPR/Cas9 editing of endogenous banana streak virus in the B genome of Musa spp. overcomes a major challenge in banana breeding
Presence of the integrated endogenous banana streak virus (eBSV) in the B genome of
plantain (AAB) is a major challenge for breeding and dissemination of hybrids. As the eBSV …
plantain (AAB) is a major challenge for breeding and dissemination of hybrids. As the eBSV …
Elimination of HIV-1 genomes from human T-lymphoid cells by CRISPR/Cas9 gene editing
We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the
entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA …
entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA …
CRISPR/Cas9-mediated genome editing of herpesviruses limits productive and latent infections
FR van Diemen, EM Kruse, MJG Hooykaas… - PLoS …, 2016 - journals.plos.org
Herpesviruses infect the majority of the human population and can cause significant
morbidity and mortality. Herpes simplex virus (HSV) type 1 causes cold sores and herpes …
morbidity and mortality. Herpes simplex virus (HSV) type 1 causes cold sores and herpes …
Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy
The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …
CRISPR-Cas9 for cancer therapy: Opportunities and challenges
Cancer is a genetic disease stemming from cumulative genetic/epigenetic aberrations.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-mediated …
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-mediated …