Reactive oxygen species and the central nervous system
B Halliwell - Journal of neurochemistry, 1992 - Wiley Online Library
Radicals are species containing one or more unpaired electrons, such as nitric oxide
(NO•−). The oxygen radical superoxide (O2•−) and the nonradical hydrogen peroxide …
(NO•−). The oxygen radical superoxide (O2•−) and the nonradical hydrogen peroxide …
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
When cells are exposed to oxidative stress, DNA damage frequently occurs. The molecular
mechanisms causing this damage may include activation of nucleases and direct reaction of …
mechanisms causing this damage may include activation of nucleases and direct reaction of …
[HTML][HTML] Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis
SA Weitzman, LI Gordon - Blood, 1990 - Elsevier
We have reviewed some of the data that link the reactive oxygen species produced by
inflammatory phagocytes to cancer development. While it is clear that these substances …
inflammatory phagocytes to cancer development. While it is clear that these substances …
The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay
D Anderson, TW Yu, BJ Phillips, P Schmezer - … Research/Fundamental and …, 1994 - Elsevier
The effects of antioxidants and various other modifying agents on oxygen-radical-generated
DNA damage in human lymphocytes have been investigated using the COMET assay …
DNA damage in human lymphocytes have been investigated using the COMET assay …
Oxidative damage to DNA in mammalian chromatin
M Dizdaroglu - Mutation Research/DNAging, 1992 - Elsevier
Efforts have been made to characterize and measure DNA modifications produced in
mammalian chromatin in vitro and in vivoby a variety of free radical-producing systems …
mammalian chromatin in vitro and in vivoby a variety of free radical-producing systems …
Iron homeostasis, oxidative stress, and DNA damage
R Meneghini - Free Radical Biology and Medicine, 1997 - Elsevier
Cellular DNA damage under prooxidant conditions has been shown to be mediated by iron.
In fact, iron is an important element in the establishment of a prooxidant status in the cell. It is …
In fact, iron is an important element in the establishment of a prooxidant status in the cell. It is …
DNA strand breakage in aquatic organisms and the potential value of the comet assay in environmental monitoring
This review considers the potential for DNA strand breaks, particularly as measured by the
comet assay, to act as a biomarker of genetic toxicity in fish and other aquatic species. The …
comet assay, to act as a biomarker of genetic toxicity in fish and other aquatic species. The …
Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or …
B Halliwell - Acta Neurologica Scandinavica, 1989 - Wiley Online Library
Radicals are species containing one or more unpaired electrons. The oxygen radical
superoxide (O2‐) and the non‐radical oxidant hydrogen peroxide (H2O2) are produced …
superoxide (O2‐) and the non‐radical oxidant hydrogen peroxide (H2O2) are produced …
The role of free radicals in asbestos-induced diseases
DW Kamp, P Graceffa, WA Pryor… - Free Radical Biology and …, 1992 - Elsevier
Asbestos exposure causes pulmonary fibrosis and malignant neoplasms by mechanisms
that remain uncertain. In this review, we explore the evidence supporting the hypothesis that …
that remain uncertain. In this review, we explore the evidence supporting the hypothesis that …
Oxygen free radicals and systemic autoimmunity
Reactive oxygen species generated during various metabolic and biochemical reactions
have multifarious effects that include oxidative damage to DNA leading to various human …
have multifarious effects that include oxidative damage to DNA leading to various human …