Purpose. NSAIDs constitute an important class of drugs with therapeutic applications that
have spanned several centuries. Treatment of inflammatory conditions such as rheumatoid …

Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and
lipoxygenase (LOX) pathways are primarily responsible for many diseases in human beings …

Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and
overexpression of this enzyme is also associated with several cancers and …

Introduction: The primary sulfonamide moiety is present in many clinically used drugs, such
as diuretics (furosemide, indapamide, chlorthalidone, thiazides); carbonic anhydrase (CA) …

Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …

A series of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (2a–h) and 1-benzoyl-3-(4-
biphenyl)-5-substituted phenyl-2-pyrazolines (3a–h) were synthesized by condensation of …

A series of 1, 3, 4-oxadiazole/thiadiazole and 1, 2, 4-triazole derivatives of biphenyl-4-yloxy
acetic acid were synthesized in order to obtain new compounds with potential anti …

In this study, a series of 5-aryl-3-alkylthio-1, 2, 4-triazoles and corresponding sulfones were
prepared with the objective of develo** better analgesic–antiinflammatory compounds …

A new set of ibuprofen-quinoline conjugates comprising quinolinyl heterocycle and
ibuprofen moieties linked by an alkyl chain were synthesized in good yields utilizing an …

Sepsis, a hyperinflammatory response that can result in multiple organ dysfunctions, is a
leading cause of mortality from infection. Here, we show that orphan nuclear receptor Nur77 …