Arterial myeloperoxidase in the detection and treatment of vulnerable atherosclerotic plaque: a new dawn for an old light
Intracellular myeloperoxidase (MPO) plays a specific role in the innate immune response;
however, upon release into the extracellular space in the setting of inflammation, drives …
however, upon release into the extracellular space in the setting of inflammation, drives …
Oxidative modification of proteins: from damage to catalysis, signaling, and beyond
Significance: The systematic investigation of oxidative modification of proteins by reactive
oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also …
oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also …
Adrenaline may contribute to prothrombotic condition via augmentation of platelet procoagulant response, enhancement of fibrin formation, and attenuation of …
A Golaszewska, T Misztal, N Marcinczyk… - Frontiers in …, 2021 - frontiersin.org
Background: Adrenaline is believed to play a role in thrombosis and hemostasis. The
complex effect of its clinically relevant concentrations on thrombus formation, coagulation …
complex effect of its clinically relevant concentrations on thrombus formation, coagulation …
Post-translational modifications of fibrinogen: implications for clotting, fibrin structure and degradation
F Nencini, A Bettiol, FR Argento, S Borghi… - Molecular …, 2024 - Springer
Fibrinogen, a blood plasma protein with a key role in hemostasis and thrombosis, is highly
susceptible to post-translational modifications (PTMs), that significantly influence clot …
susceptible to post-translational modifications (PTMs), that significantly influence clot …
Acute inhalation toxicity of aerosolized electrochemically generated solution of sodium hypochlorite
Objective The objective was to determine the inhalation toxicity of the electrochemically
generated sodium hypochlorite solution after its single administration to laboratory animals …
generated sodium hypochlorite solution after its single administration to laboratory animals …
Platelets and fibrinogen: emerging complexity in trauma-induced coagulopathy
AE John, NJ White - Seminars in thrombosis and hemostasis, 2020 - thieme-connect.com
Trauma induces a change in nearly every observable aspect of hemostasis, generally
tip** the balance toward trauma-induced coagulopathy (TIC) and bleeding in the critical …
tip** the balance toward trauma-induced coagulopathy (TIC) and bleeding in the critical …
[HTML][HTML] N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies
N-chlorotaurine (NCT) is a broad-spectrum antimicrobial agent with outstanding tolerability,
effective for topical and inhalation use. This paper presents the results of studies of single …
effective for topical and inhalation use. This paper presents the results of studies of single …
Lung injury and oxidative stress induced by inhaled chlorine in mice is associated with proinflammatory activation of macrophages and altered bioenergetics
R Malaviya, CR Gardner, RC Rancourt… - Toxicology and applied …, 2023 - Elsevier
Chlorine (Cl 2) gas is a highly toxic and oxidizing irritant that causes life-threatening lung
injuries. Herein, we investigated the impact of Cl 2-induced injury and oxidative stress on …
injuries. Herein, we investigated the impact of Cl 2-induced injury and oxidative stress on …
[HTML][HTML] Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma
N Manucat-Tan, RZ Abdallah, H Kaur, D Saviane… - Redox biology, 2021 - Elsevier
Fibrinogen, a major constituent of blood plasma, is highly susceptible to reaction with
biological oxidants. It has been proposed that fibrinogen plays a role in antioxidant defence …
biological oxidants. It has been proposed that fibrinogen plays a role in antioxidant defence …
Platelet inhibition by hypochlorous acid involves cAMP signalling
Hypochlorous acid (HOCl), made by neutrophil-derived myeloperoxidase, has been
suggested to inhibit platelets, however, the mechanisms involved have not been described …
suggested to inhibit platelets, however, the mechanisms involved have not been described …